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    • Nucleotide Excision Repair
    • Mechanisms of CDK regulation
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    • Previous Research >
      • Structure of TFIIH
      • Large Assemblies
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      • Ribsosome Biogenesis
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THE GREBER LABORATORY
  • Home
  • Research
    • Nucleotide Excision Repair
    • Mechanisms of CDK regulation
    • High-Resolution Cryo-EM
    • Previous Research >
      • Structure of TFIIH
      • Large Assemblies
      • Mitochondrial Ribosomes
      • Ribsosome Biogenesis
  • People
    • Overview
    • Dr. Basil Greber's CV
  • Publications
    • Selected Publications
    • Chronological Publication Record
  • Contact

List of Publications

Chronological publication record

Pre-prints undergoing peer review

New pre-prints will be listed in this section until they have been accepted for publication in a journal.

2026

Feng J, Martin PR, Kowalski S, Lecot M, Cronin NB, Matthews-Palmer T, Niedzwiedz W, Greber BJ# (2026) 
Molecular basis of XPF-ERCC1 targeting to SLX4-dependent DNA repair pathways.
Nat. Commun. 17: 522. #corresponding author. Link

2025


Cushing VI, McGeoch AJS, Williams SL, Roumeliotis TI, Feng J, Dan LM, Choudhary JS, Davey NE, Greber BJ# (2025).
Structural basis of T-loop-independent recognition and activation of CDKs by the CDK-activating kinase.
Science 390 (6776): 911-917. #corresponding author. Link

Lai C-F, Cushing VI, Olden E, Bevan CL, Coombes RC, Greber BJ#, Buluwela L#, Ali S# (2025).
Resistance to CDK7 inhibitors directed by acquired mutation of a conserved residue in cancer cells.
EMBO J. 44: 5860-5889. #corresponding authors. Link

Örd M, Winters MJ, Subbanna MS, de Martín Garrido N, Cushing VI, Kliche J, Benz C, Ivarsson Y, Greber BJ, Pryciak PM, Davey NE (2025).
High-throughput investigation of cyclin docking interactions reveals the complexity of motif binding determinants.
Nat. Commun. 16: 7622. Link

bioRxiv, doi: 10.1101/2024.12.03.625240. Link

Karia D, Koh AF, Yang W, Cushing VI, Basanta B, Mihaylov DB, Khavnekar S, Vyroubal O, Malínský M, Sháněl O, Doležal V, Plitzko JM, Yu L, Lander GC, Aricescu AR, Greber BJ, Kotecha A (2025).
Sub-3 Å resolution protein structure determination by single-particle cryo-EM at 100 keV.
Structure 33 (10): 1717-1727.e4. 
Link
bioRxiv, doi: 10.1101/2024.09.05.611417. Link

Jones T*, Feng J*, Luyties O, Cozzolino K, Sanford L, Rimel JK, Ebmeier CC, Shelby GS, Watts LP, Rodino J, Rajagopal N, Hu S, Brennan F, Maas ZL, Alnemy S, Richter WF, Koh AF, Cronin NB, Madduri A, Das J, Cooper E, Hamman KB, Carulli JP, Allen MA, Spencer S, Kotecha A, Marineau JJ#, Greber BJ#, Dowell RD#, Taatjes DJ# (2025).
TFIIH kinase CDK7 drives cell proliferation through a common core transcription factor network.
Sci. Adv. 10: adr9660. *equal contribution #corresponding authors. Link

2024

​Greber BJ# (2024).
High-resolution cryo-EM of a small protein complex: The structure of the human CDK-activating kinase.
Structure 32 (4): 380-392. #corresponding author Link

Cushing VI, Koh AF, Feng J, Jurgaityte K, Bondke A, Kroll SHB, Barbazanges M, Scheiper B, Bahl AK, Barret AGM, Ali S#, Kotecha A#, Greber BJ# (2024).
High-resolution cryo-electron microscopy of the human CDK-activating kinase for structure-based drug design.
Nat. Commun. 15: 2265. #corresponding authors Link

bioRxiv, doi: 10.1101​/2023.04.07.536029. Link

Zhong Y*, Feng J*, Koh AF, Kotecha A, Greber BJ#, Ataide SF# (2024).
Cryo-EM structure of SRP68/72 reveals an extended dimerization domain with RNA-binding activity.
Nucleic Acids Res. 52 (9): 5285-5300. *equal contribution #corresponding authors Link

Sauer PV*, Cupellini L*, Sutter M*, Bondanza M, Kirst H, Bina D, Koh AF, Kotecha A, Greber BJ, Nogales E, Polivka T, Menucci B, Kerfeld CA,   (2024).
Structural and quantum chemical basis for OCP-mediated quenching of phycobilisomes.
Sci. Adv. 10: eadk7535. *equal contribution Link

2023

Ferlez BH, Kirst H, Greber BJ, Nogales E, Sutter M, Kerfeld CA (2023).
Heterologous assembly of pleomorphic bacterial microcompartment shell architectures spanning the nano‐ to microscale
Adv. Mat. 35 (23): 2212065 Link

2022

Domínguez-Martín MA*,  Sauer PV*,  Kirst H, Sutter M, Bína D, Greber BJ, Nogales E, Polívka T, Kerfeld CA (2022).
Structures of a phycobilisome in light-harvesting and photo protected states.  
Nature 609 (7928): 835-845. *equal contribution Link

LaFrance BJ,  Roostalu J,  Henkin G, Greber BJ, Zhang R, Normanno D, McCollum CO, Surrey T, Nogales E (2022). 
Structural transitions in the GTP cap visualized by cryo-electron microscopy of catalytically inactive microtubules.  
Proc. Natl. Acad. Sci. U.S.A. 119: e2114994119. Link

2021

Greber BJ (2021). 
Merging data from structurally homogeneous subsets. 
In: Glaeser RM, Nogales E, Chiu W (eds.) (2021). 
Single-particle Cryo-EM of Biological Macromolecules (pp. 4.20-4.37). IOP Publishing. Link

Greber BJ#, Remis J, Ali S, Nogales E (2021). 
2.5 Å-resolution structure of the human CDK-activating kinase bound to the clinical inhibitor ICEC0942. 
Biophys. J. 120 (4): 677-686. #corresponding author. PubMed

2020

Greber BJ#, Perez-Bertoldi JM, Lim K, Iavarone AT, Nogales E# (2020). 
The cryoelectron microscopy structure of the human CDK-activating kinase. 
Proc. Natl. Acad. Sci. U.S.A. 549 (7672): 414-417. #corresponding authors PubMed
bioRxiv, doi: 10.1101/2020.05.13.094755. Posted 2020 May 13. Link

Patel AB, Greber BJ, Nogales E (2020). 
Recent insights into the structure of TFIID, its assembly, and its binding to core promoter. 
Curr. Opin. Struct. Biol. 61: 17-24. PubMed

Mena EL, Jevtić P, Greber BJ, Gee CL, Lew BG, Akopian D, Nogales E, Kuriyan J, Rape M (2020).
Structural basis for dimerization quality control.
Nature 586 (7829): 452-456. PubMed

2019

Greber BJ, Toso DB, Fang J, Nogales E (2019). 
The complete structure of the human TFIIH core complex. 
eLife 8: e44771. PubMed
bioRxiv, doi: 10.1101/507723. Link

Greber BJ#, Nogales E (2019). 
The structures of eukaryotic transcription pre-initiation complexes and their functional implications. 
In: Harris, J.R., Marles-Wright, J. (eds.) (2019). 
Subcellular Biochemistry 93: 143-192. #corresponding author 
Macromolecular Protein Complexes II: Structure and Function. Springer. PubMed

Greber BJ*, Sutter M*, Kerfeld CA (2019). 
The plasticity of molecular interactions governs bacterial microcompartment shell assembly. 
Structure 27 (5): 749-763.e4. *equal contribution PubMed

Patel AB*, Moore CM*, Greber BJ*, Luo J, Zukin SA, Ranish J, Nogales E (2019). 
Architecture of the chromatin remodeler RSC and insights into its nucleosome engagement. 
eLife 8: e54449. *equal contribution PubMed

Nogales E#, Greber BJ# (2019). 
High-resolution cryo-EM structures of TFIIH and their functional implications. 
Curr. Opin. Struct. Biol. 59: 188-194. #corresponding authors PubMed

2018

Patel AB, Louder RK, Greber BJ, Grünberg S, Luo J, Fang J, Liu Y, Ranish J, Hahn S, Nogales E (2018). 
Structure of human TFIID and mechanism of TBP loading onto promoter DNA. 
Science 362 (6421): eaau8872. PubMed

Nguyen THD, Tam J, Wu RA, Greber BJ, Toso D, Nogales E, Collins K (2018). 
Cryo-EM structure of substrate-bound human telomerase holoenzyme. 
Nature 557 (7704): 190-195. PubMed

Bieri P, Greber BJ, Ban N (2018). 
High-resolution structures of mitochondrial ribosomes and their functional implications. 
Curr. Opin. Struct. Biol. 49: 44-53. PubMed

2017

Greber BJ, Nguyen THD, Fang J, Afonine PV, Adams PD, Nogales E (2017). 
The cryo-electron microscopy structure of human transcription factor IIH. 
Nature 549 (7672): 414-417. PubMed

Sutter M, Greber B, Aussignargues C, Kerfeld CA (2017). 
Assembly principles and structure of a 6.5-MDa bacterial microcompartment shell. 
Science 356 (6344): 1293-1297. PubMed F1000Prime

2016

Greber BJ (2016). 
Mechanistic insight into eukaryotic 60S ribosomal subunit biogenesis by cryo-electron microscopy. 
RNA 22 (11): 1643-1662. PubMed 

Greber BJ, Ban N (2016).
Structure and function of the mitochondrial ribosome.
Annu. Rev. Biochem. 85 (1): 103-132. PubMed

Greber BJ*, Gerhardy S*, Leitner A, Leibundgut M, Salem M, Boehringer D, Leulliot N, Aebersold R, Panse VG, Ban N (2016).
Insertion of the biogenesis factor Rei1 probes the ribosomal tunnel during 60S maturation.
Cell 164 (1-2): 91-102. Epub 2015 Dec 17. *equal contribution PubMed

Bar-Yaacov D, Frumkin I, Yashiro Y, Chujo T, Ishigami Y, Chemla Y, Blumberg A, Schlesinger O, Bieri P, Greber B, Ban N, Zarivach R, Alfonta L, Pilpel Y, Suzuki T, Mishmar D (2016). 
Mitochondrial 16S rRNA is methylated by tRNA methyltransferase TRMT61B in all vertebrates. 
PLoS Biol. 14 (9): e1002557. PubMed 

2015

Greber BJ*, Bieri P*, Leibundgut M*, Leitner A, Aebersold R, Boehringer D, Ban N (2015).
The complete structure of the 55S mammalian mitochondrial ribosome.
Science 348 (6232): 303-308. *equal contribution PubMed

2014

Greber BJ*, Boehringer D*, Leibundgut M*, Bieri P, Leitner A, Schmitz N, Aebersold R, Ban N (2014).
The complete structure of the large subunit of the mammalian mitochondrial ribosome.
Nature 515 (7526): 283–286. *equal contribution PubMed

Greber BJ*, Boehringer D*, Leitner A, Bieri P, Voigts-Hoffman F, Erzberger JP, Leibundgut M, Aebersold R, Ban N (2014).
Architecture of the large subunit of the mammalian mitochondrial ribosome.
Nature 505 (7484): 515–519. *equal contribution PubMed F1000Prime

Godinic-Mikulcic V, Jaric J, Greber BJ, Franke V, Hodnik V, Anderluh G, Ban N, Weygand-Durasevic I (2014).
Archaeal aminoacyl-tRNA synthetases interact with the ribosome to recycle tRNAs.
Nucleic Acids Res. 42 (8): 5191-201. PubMed

2013

Greber BJ (2013).
​Cryo-electron microscopy structures of large ribosomal subunit complexes
Doctoral Thesis, Eidgenössische Technische Hochschule ETH Zürich, Diss. Nr. 21280

2012 and prior

Greber BJ, Boehringer D, Montellese C, Ban N (2012).
Cryo-EM Structures of Arx1 and Maturation Factors Rei1 and Jjj1 Bound to the 60S Ribosomal Subunit.
Nat. Struct. Mol. Biol. 19 (12): 1228-33. PubMed

Greber BJ, Boehringer D, Godinic-Mikulcic V, Crnkovic A, Ibba M, Weygand-Durasevic I, Ban N (2012).
Cryo-EM Structure of the Archaeal 50S Ribosomal Subunit in Complex with Initiation Factor 6 and Implications for Ribosome Evolution.
J. Mol. Biol. 418 (3-4): 145-160. PubMed

Boehringer D, Greber B, Ban N (2011).
Mechanistic Insight into Co-Translational Protein Processing, Folding, Targeting, and Membrane Insertion.
In: Rodnina M, Wintermeyer W, Green R (eds.) (2011). Ribosomes: Structure, Function, and Dynamics. Springer, Vienna.

Neurohr G*, Naegeli A*, Titos I, Theler D, Greber B, Díez J, Gabaldón T, Mendoza M, Barral Y (2011).
A midzone-based ruler adjusts chromosome compaction to anaphase spindle length.
Science 332 (6028): 465-8. *equal contribution PubMed

Kohler R*, Boehringer D*, Greber B, Bingel-Erlenmeyer R, Collinson I, Schaffitzel C, Ban N (2009).
YidC and Oxa1 form dimeric insertion pores on the translating ribosome.
Mol. Cell 34: 344-53. *equal contribution PubMed F1000Prime

For a list of Basil Greber's publications in PubMed, click here.

The Greber Laboratory
Division of Structural Biology
Institute of Cancer Research
London, UK
Picture
© copyright Basil Greber 2020-2025
  • Home
  • Research
    • Nucleotide Excision Repair
    • Mechanisms of CDK regulation
    • High-Resolution Cryo-EM
    • Previous Research >
      • Structure of TFIIH
      • Large Assemblies
      • Mitochondrial Ribosomes
      • Ribsosome Biogenesis
  • People
    • Overview
    • Dr. Basil Greber's CV
  • Publications
    • Selected Publications
    • Chronological Publication Record
  • Contact