Learn more about the group
We are part of the Division of Structural Biology at the Institute of Cancer Research in London.
Research
Explore our research on nucleotide excision repair and read about challenges in cryo-EM
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The Lab
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Publications
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News from the lab
Structure of the CDK-activating kinase bound to ICEC0942January 19, 2021
Our latest paper reports the 2.5 Å-resolution structure of the CDK-activating kinase bound to the inhibitor ICEC0942 and has been published in the Biophysical Journal. This work was a collaboration with the laboratory of Prof. Simak Ali at Imperial College London and the data were collected during Basil's final days in the Nogales Lab in Berkeley. |
Read about our workOctober 6, 2020
Céleste Nilges spoke to Basil about his past work and the new lab. Read about it in this blog post on the ICR website. |
Raw data available on EMPIAROctober, 2020
The raw data used for structure determination of the CDK-activating kinase is now available on EMPIAR: CAK-nucleotide complex: www.ebi.ac.uk/pdbe/emdb/empiar/entry/10431/ CAK-THZ1 complex: www.ebi.ac.uk/pdbe/emdb/empiar/entry/10438/ |
Structure of the human CDK-activating kinaseAugust 27, 2020
Basil's work on the structure of the CDK-activating kinase, performed in the Nogales Lab in Berkeley, has been published in PNAS. |