News from the lab
February 16th, 2024
In collaboration with the groups of Prof. Sandro Ataide (University of Sydney) and Dr. Abhay Kotecha (Thermo Fisher Scientific), Junjie determined the structure of the protein-binding domain of the SRP68/72 dimer, which forms part of the eukaryotic signal recognition particle. Read all about it at Nucleic Acids Research.
New job opening!
May 6th, 2023
We are looking for a post-doctoral training fellow to join the lab and pursue structural and functional studies of DNA repair and related processes. Candidates with prior expertise in the biochemistry of nucleic acid-protein complexes or in structural biology/cryo-EM are encouraged to apply. Application deadline is June 4th, 2023.
April 12th, 2023
We just published the lab's first pre-print! Together with collaborators at Thermo Fisher Scientific and Imperial College, we developed high-resolution and high-throughput cryo-EM workflows for structure-based drug design. We screened large numbers of grids and determined almost 20 structures of inhibitor-bound CAK at 2 Å from the best ones. Have a look on bioRxiv!
New lab space & new lab members
August 23, 2021
We have moved into our newly refurbished lab space a few weeks ago (pictured on the left in its pristine state, though now already filled with lots of instruments and consumables). Junjie has joined the lab as a postdoc at the beginning of the month. Victoria (PhD student) and Natalia (postdoc) will join in the next few months to complete the team.
We are (still) recruiting!
June 1, 2021
Two new lab members have been recruited: Junjie and Victoria will join the lab in the summer and fall, respectively. To expand our team, we are still looking for an MRC-funded post-doctoral training fellow to join the lab. Candidates with prior expertise in the biochemistry of nucleic acid-protein complexes or in structural biology are encouraged to apply. Learn more about this opportunity here.
Structure of the CDK-activating kinase bound to ICEC0942
January 19, 2021
Our latest paper reports the 2.5 Å-resolution structure of the CDK-activating kinase bound to the inhibitor ICEC0942 and has been published in the Biophysical Journal. This work was a collaboration with the laboratory of Prof. Simak Ali at Imperial College London and the data were collected during Basil's final days in the Nogales Lab in Berkeley.
Read about our work
October 6, 2020
Céleste Nilges spoke to Basil about his past work and the new lab. Read about it in this blog post on the ICR website.